Search results for "cancer mortality"

Diesel motor emissions and lung cancer mortality--results of the second follow-up of a cohort study in potash miners.

2009

International health authorities have graded diesel motor emissions (DME) as probably cancerogenic in human beings. There are gaps in epidemiological evidence regarding exact exposure quantification, confounder control and the investigation of highly exposed populations. We investigated the association of DME ana lung cancer mortality in a historical cohort study of 5,862 German potash miners who were followed from 1970 to 2001. Cumulative exposure (CE) was measured by representative concentrations of total carbon multiplied with exposure years from the mines' medical records. Exposure and smoking behavior were validated by interviews of 3,087 participants. We computed standardized mortalit…

Detection of precancerous gastric lesions and gastric cancer through exhaled breath.

2015

Timely detection of gastric cancer (GC) and the related precancerous lesions could provide a tool for decreasing both cancer mortality and incidence.968 breath samples were collected from 484 patients (including 99 with GC) for two different analyses. The first sample was analysed by gas chromatography linked to mass spectrometry (GCMS) while applying t test with multiple corrections (p value0.017); the second by cross-reactive nanoarrays combined with pattern recognition. For the latter, 70% of the samples were randomly selected and used in the training set while the remaining 30% constituted the validation set. The operative link on gastric intestinal metaplasia (OLGIM) assessment staging…

Predictions of cancer mortality in Europe in 2021: room for hope in the shadow of COVID-19?

2021

Quantification of exposure to dioxins and furans in a cohort of workers of a herbicide producing plant in hamburg, FRG

1992

Abstract To assess the exposure to PCDD/Fs of a cohort of 1583 workers of a herbicide producing plant in Hamburg, FRG, investigated for cancer mortality, measurements of PCDD/Fs in fat tissue (n=48) or blood (n=64) were analyzed according to work histories in a subgroup of n=112 male workers. In a multiple regression analysis the time of work in the production of 2,4,5-T and 2,4,5-TCP, for the latter especially before 1957, correlated well with the levels of 2378-tetrachlorodibenzo-p-dioxin (TCDD). For most of the higher chlorinated isomers time of work in the thermic decomposition showed the strongest effect. The results confirm that the developed indicators are good proxis for exposure to…

The 15-Country Collaborative Study of Cancer Risk Among Radiation Workers in the Nuclear Industry: design, epidemiological methods and descriptive re…

2007

International audience; Radiation protection standards are based mainly on risk estimates from studies of atomic bomb survivors in Japan. The validity of extrapolations from the relatively high-dose acute exposures in this population to the low-dose, protracted or fractionated environmental and occupational exposures of primary public health concern has long been the subject of controversy. A collaborative retrospective cohort study was conducted to provide direct estimates of cancer risk after low-dose protracted exposures. The study included nearly 600,000 workers employed in 154 facilities in 15 countries. This paper describes the design, methods and results of descriptive analyses of th…

Sentieri: mortality, cancer incidence and hospital discharges. Summary

2014

The 15-Country Collaborative Study of Cancer Risk among Radiation Workers in the Nuclear Industry: Estimates of Radiation-Related Cancer Risks

2007

International audience; A 15-Country collaborative cohort study was conducted to provide direct estimates of cancer risk following protracted low doses of ionizing radiation. Analyses included 407,391 nuclear industry workers monitored individually for external radiation and 5.2 million person-years of follow-up. A significant association was seen between radiation dose and all-cause mortality [excess relative risk (ERR) 0.42 per Sv, 90% CI 0.07, 0.79; 18,993 deaths]. This was mainly attributable to a dose-related increase in all cancer mortality (ERR/Sv 0.97, 90% CI 0.28, 1.77; 5233 deaths). Among 31 specific types of malignancies studied, a significant association was found for lung cance…

Spatial Interaction between Neighbouring Counties: Cancer Mortality Data in Valencia (Spain)

1995

The statistical analysis of geographical mortality data has usually been approached via regression models that include appropriate covariates. These models assume stochastic independence of mortality counts for neighbouring sites, a questionable assumption that spatial automodels (Besag, 1974, Journal of the Royal Statistical Society, Series B 36, 192-236) make unnecessary. This paper presents the use of the autopoisson distribution in order to detect spatial interaction between neighbouring sites. If this interaction results in being nonsignificant, the auto-Poisson distribution reduces to a usual Poisson regression model, a particular case of generalized linear models (McCullagh and Nelde…

Cancer mortality inequalities in urban areas: a Bayesian small area analysis in Spanish cities

2011

incluye "Erratum to: Cancer mortality inequalities in urban areas: a Bayesian small area analysis in Spanish cities" BACKGROUND: Intra-urban inequalities in mortality have been infrequently analysed in European contexts. The aim of the present study was to analyse patterns of cancer mortality and their relationship with socioeconomic deprivation in small areas in 11 Spanish cities. METHODS: It is a cross-sectional ecological design using mortality data (years 1996-2003). Units of analysis were the census tracts. A deprivation index was calculated for each census tract. In order to control the variability in estimating the risk of dying we used Bayesian models. We present the RR of the censu…

Open Radical Nephrectomy: 35 Years of Experience at the “Luciano Giuliani” Urological Department of the University of Genoa

2006

Objective: Radical nephrectomy remains the gold standard for surgically resectable kidney neoplasms > 4 cm and, in selected cases, also in presence of metastatic disease. We reviewed the records of the patients having surgery at the University of Genoa in the last 35 yr. Methods: We have retrospectively assessed all the radical nephrectomies performed between 1970 and 2005. Among tumours of the kidney subjected to surgical treatment during this period, we found 1105 cases of histologically proven renal cell carcinoma (RCC), 965 of which had records available for the study. The number of cases per year, symptoms at diagnosis, surgical strategy, staging of the tumour, and survival were rev…